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Phenotypes Associated with This Genotype
Genotype
MGI:5576517
Allelic
Composition
Tg(Wap-Hgf)402Mig/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-Hgf)402Mig mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age
• tumors have a complex glandular and squamous pattern with extensive necrosis
• tumors show malignancy markers
• profuse squamous metaplasia in tumors and lung metastasis
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• most females develop multi-focal tumors in more than one gland after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age
• 12 of 55 females show lung metastases

endocrine/exocrine glands
• a thick layer of fibroblasts surround the mammary epithelium in virgin females
• mammary ductal trees of virgin females have an altered morphology characterized by abundant lobular structures protruding from ducts resembling aborted branches covering the ductal surface
• virgin females exhibit hyperplastic ductal trees
• hyperplastic ductal trees are seen upon involution
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age
• tumors have a complex glandular and squamous pattern with extensive necrosis
• tumors show malignancy markers
• profuse squamous metaplasia in tumors and lung metastasis
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• most females develop multi-focal tumors in more than one gland after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age

integument
• a thick layer of fibroblasts surround the mammary epithelium in virgin females
• mammary ductal trees of virgin females have an altered morphology characterized by abundant lobular structures protruding from ducts resembling aborted branches covering the ductal surface
• virgin females exhibit hyperplastic ductal trees
• hyperplastic ductal trees are seen upon involution
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age
• tumors have a complex glandular and squamous pattern with extensive necrosis
• tumors show malignancy markers
• profuse squamous metaplasia in tumors and lung metastasis
• 49 out of 55 females develop fast-growing adenocarcinomas after several pregnancies
• most females develop multi-focal tumors in more than one gland after several pregnancies
• 10 of 50 virgin females develop one or multiple tumors before 1 year of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:86776


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory