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Phenotypes Associated with This Genotype
Genotype
MGI:5576171
Allelic
Composition
Tg(Myh6-TNNT2*R141W)#Lian/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• premature death beginning at 4 months of age, with 11.1% immature death between 4 and 8 months of age

cardiovascular system
• increase in interstitial collagen content
• increase in expression of markers of cardiac hypertrophy and hypertrophic myocardiocytes
• the left ventricular end-systolic diameter and end-diastolic diameter are increased by 58.3% and 27.8%, respectively, at 4 months of age
• the left ventricular systolic volume and diastolic volume are increased by 191.2% and by 75.9%, respectively, at 4 months of age
• thinner wall of left ventricle
• increase in interstitial collagen content
• both left ventricular systolic volume and left ventricular diastolic volume are increased about 2-fold at 8 months, while percent ejection fraction is decreased by 36.7% at 8 months and percent fractional shortening decreased by 39.7% at 8 months
• percent ejection fraction and percent fractional shorting are decreased by 39.9% and 45.4%, respectively, at 4 months of age
• interventricular septal movement and posterior wall movement is decreased by 40.3% and 47.9%, respectively, at 4 months of age

homeostasis/metabolism
• mural thrombi

muscle
• increase in interstitial collagen content
• both left ventricular systolic volume and left ventricular diastolic volume are increased about 2-fold at 8 months, while percent ejection fraction is decreased by 36.7% at 8 months and percent fractional shortening decreased by 39.7% at 8 months
• percent ejection fraction and percent fractional shorting are decreased by 39.9% and 45.4%, respectively, at 4 months of age
• interventricular septal movement and posterior wall movement is decreased by 40.3% and 47.9%, respectively, at 4 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1D DOID:0110426 OMIM:601494
J:211769


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory