Phenotypes Associated with This Genotype

Genotype
MGI:5575767

• Allelic Composition: Mir1a-2^tm1Dsr/Mir1a-2^tm1Dsr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:211548 )

• occasional sudden death in adult mice

lethality during fetal growth through weaning, incomplete penetrance ( J:211548 )

• 50% lethality by weaning

• most deaths occur from E15.5 to shortly after birth

cardiovascular system

abnormal heart morphology ( J:211548 )

abnormal myocardium layer morphology ( J:211548 )

• 20% increase in the number of cardiomyocytes

• extended period of cell division

ventricular septal defect ( J:211548 )

• large septal defects in about 50% of embryos leads to death within a few hours of birth

enlarged heart ( J:211548 )

• embryonic hearts occasionally are somewhat enlarged but superficially appear normal otherwise

increased heart weight ( J:211548 )

• increased heart to body weight ratio at 4 to 6 months of age

thick ventricular wall ( J:211548 )

• determined by echocardiography

pericardial edema ( J:211548 )

• sometimes, before birth

dilated heart ( J:211548 )

• develops rapidly in about 15% of surviving mice

abnormal cardiovascular system physiology ( J:211548 )

• appears by 2-3 months of age in about 15% of survivors

decreased heart rate ( J:211548 )

• significantly reduced heart rate

abnormal heart electrocardiography waveform feature ( J:211548 )

• shortened delay between atrial and ventricular depolarizations

prolonged QRS complex duration ( J:211548 )

homeostasis/metabolism

pericardial edema ( J:211548 )

• sometimes, before birth

abnormal atrial thrombosis ( J:211548 )

• atrial thrombi found in about 15% of survivors by 2-3 months of age

• atrial thrombi lead to death

muscle

abnormal myocardium layer morphology ( J:211548 )

• 20% increase in the number of cardiomyocytes

• extended period of cell division

growth/size/body

enlarged heart ( J:211548 )

• embryonic hearts occasionally are somewhat enlarged but superficially appear normal otherwise

increased heart weight ( J:211548 )

• increased heart to body weight ratio at 4 to 6 months of age