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Phenotypes Associated with This Genotype
Genotype
MGI:5574228
Allelic
Composition		 Grin1tm1Jjwd/Grin1tm1Jjwd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Jjwd mutation (0 available); any Grin1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:209690 )
• no mice are present at P21 despite normal Mendelian ratios at E18

nervous system
abnormal NMDA-mediated synaptic currents ( J:209690 )
• ethanol inhibition of NMDA current is impaired compared to in wild-type mice
• however, NMDA evoked currents are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory