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Phenotypes Associated with This Genotype
Genotype
MGI:5574073
Allelic
Composition
Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation (2 available); any Cdkl5 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hind-limb clasping in Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr mice

behavior/neurological
• in the home cage
• however, activity in a novel open arena is normal
• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences

nervous system
• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings
• however, mice exhibit normal spontaneous and induced seizure occurrences
• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice
• however, mice exhibit normal spontaneous and induced seizure occurrences

vision/eye
• decreased amplitude, but not latency, of the first positive wave

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 2 DOID:0080467 OMIM:300672
J:209635


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory