Phenotypes for Cdkl5 MGI:5574072 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:209635 )

decreased locomotor activity ( J:209635 )

• intermediate in the home cage

• however, activity in a novel open arena is normal

vision/eye

abnormal visual evoked potential ( J:209635 )

• decreased amplitude, but not latency, of the first positive wave

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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