Phenotypes Associated with This Genotype

Genotype
MGI:5573177

• Allelic Composition: Dab1^scm-6J/Dab1^scm-6J
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellar foliation ( J:211099 )

abnormal hippocampus morphology ( J:211099 )

abnormal hippocampus layer morphology ( J:211099 )

• scrambled layers in the hippocampus

abnormal cerebral cortex morphology ( J:211099 )

• cerebral cortex lacks the normal layered pattern

abnormal stratification in cerebral cortex ( J:211099 )

abnormal cerebellar Purkinje cell layer ( J:211099 )

• scattered granule and Purkinje cells

abnormal cerebellar granule layer morphology ( J:211099 )

• scattered granule and Purkinje cells

cerebellum hypoplasia ( J:211099 )

growth/size/body

decreased body size ( J:211099 )

• homozygotes are smaller than normal and thin by 2 weeks of age

behavior/neurological

impaired righting response ( J:211099 )

ataxia ( J:211099 )

• homozygotes lean on their sides, unable to right themselves

impaired balance ( J:211099 )

mortality/aging

postnatal lethality, complete penetrance ( J:211099 )

• all homozygotes die by three to four weeks of age