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Phenotypes Associated with This Genotype
Genotype
MGI:5573165
Allelic
Composition
Insm1tm1Cbm/Insm1tm1Cbm
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insm1tm1Cbm mutation (0 available); any Insm1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased melanocyte-stimulating hormone, prolactin and adrenocorticotropin levels
• absent growth hormone, follicle stimulating hormone, thyroid-stimulating hormone and luteinizing hormone levels
• absent at E17.5

nervous system
• as determined by the lack of growth hormone at E17.5
• mice exhibit an increase in endocrine progenitor cells compared with wild-type mice
• however, mice exhibit normal distribution and morphology of fibroblasts, folliculostellate cells and endothelia

endocrine/exocrine glands
• as determined by the lack of growth hormone at E17.5
• mice exhibit an increase in endocrine progenitor cells compared with wild-type mice
• however, mice exhibit normal distribution and morphology of fibroblasts, folliculostellate cells and endothelia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory