Phenotypes Associated with This Genotype

Genotype
MGI:5573137

• Allelic Composition: Mcu^{Gt(IST11669F8)Tigm}/Mcu^{Gt(IST11669F8)Tigm}
• Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208297 )

N • mice exhibit normal total body oxygen consumption

impaired exercise endurance ( J:208297 )

increased circulating lactate level ( J:208297 )

• increased serum lactate levels

cellular

cellular phenotype ( J:208297 )

N • mice exhibit normal cell death

abnormal mitochondrial physiology ( J:208297 )

• mitochondria from skeletal muscle, mouse embryonic fibroblast and adult cardiac myocytes exhibit impaired calcium uptake compared with wild-type mitochondria

• cardiac and hepatic mitochondria fail to exhibit calcium-induced permeability transition pore opening unlike in wild-type mitochondria

growth/size/body

decreased body size ( J:208297 )

decreased body weight ( J:208297 )

behavior/neurological

decreased grip strength ( J:208297 )

• small

impaired exercise endurance ( J:208297 )

cardiovascular system

cardiovascular system phenotype ( J:208297 )

N • mice exhibit normal response to ischemia-reperfusion injury