Phenotypes Associated with This Genotype

Genotype
MGI:5573127

• Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Germinal centers and follicular dendritic cell networks are absent in Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt mice immunized with sheep red blood cells

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:210950 )

• all mice infected with Listeria monocytogenes die unlike wild-type mice

decreased susceptibility to induced morbidity/mortality ( J:210950 )

• no mice treated with TNF die unlike wild-type mice

immune system

impaired humoral immune response ( J:210950 )

• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:210950 )

• all mice infected with Listeria monocytogenes die unlike wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:210950 )

• TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

cellular

increased sensitivity to induced cell death ( J:210950 )

• in mouse embryonic fibroblasts exposed to hypoxia