Phenotypes Associated with This Genotype

Genotype
MGI:5572833

• Allelic Composition: Tg(Gh-Gal)4599Vron/?
• Genetic Background: involves: C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pituitary gland hyperplasia ( J:86486 )

• pituitary gland is visibly larger in transgenic animals by 12 months of age

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age

homeostasis/metabolism

increased circulating prolactin level ( J:86486 )

• prolactin serum levels are increased in both sexes, but the increase is greater in males (9 fold versus 2 fold)

• increase in prolactin serum levels is correlated with increase in galanin serum levels in male transgenic mice

increased circulating growth hormone level ( J:86486 )

♂ • growth hormone levels are increased in both sexes, but the increase is only significant in males

nervous system

pituitary gland hyperplasia ( J:86486 )

• pituitary gland is visibly larger in transgenic animals by 12 months of age

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age

neoplasm

increased pituitary adenoma incidence ( J:86486 )

• pituitary adenomas are observed in mice at 8 months of age