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Phenotypes Associated with This Genotype
Genotype
MGI:5571490
Allelic
Composition		 Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1084 available)
Kittm1.1(cre)Jmol mutation (1 available); any Kit mutation (175 available)
Kittm2.1(cre/Esr1*)Jmol mutation (1 available); any Kit mutation (175 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:210584 )
• animals die at birth, but viable fetuses are observed at E16.5 and E18.5; no Kit protein is detected by Western blot

cardiovascular system
abnormal heart development ( J:210584 )
• at E16.5, hearts have lower total numbers of EGFP-positive cells compared to controls, and no EGFP-positive cardiomyocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory