Phenotypes Associated with This Genotype

Genotype
MGI:5571468

• Allelic Composition: \Adam17^tm1.1Wesh/\Adam17^tm1.1Wesh; \Tg(Scgb1a1-rtTA)2Jaw/0; \Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:210193 )

N • doxycycline-treated mice exhibit normal neonatal survival

respiratory system

abnormal lung vasculature morphology ( J:210193 )

• reduced pulmonary capillary formation in doxycycline-treated mice

abnormal lung saccule morphology ( J:210193 )

• at E18.5, doxycycline-treated mice exhibit reduced terminal sacs and thickened surrounding mesenchyme in the peripheral lung compared with control mice

• larger but fewer sacs at P1 in doxycycline-treated mice

• however, morphology at P14 and P30 is normal

thick lung-associated mesenchyme ( J:210193 )

• at E18.5 in doxycycline-treated mice

abnormal lung epithelium morphology ( J:210193 )

• impaired epithelial cell differentiation in doxycycline-treated mice

cellular

decreased cell proliferation ( J:210193 )

• at P1, but not P30, in the lungs of doxycycline-treated mice

cardiovascular system

abnormal lung vasculature morphology ( J:210193 )

• reduced pulmonary capillary formation in doxycycline-treated mice