Phenotypes Associated with This Genotype

Genotype
MGI:5571382

• Allelic Composition: Hk2^tm1.1Uku/Hk2^tm1.1Uku; Tg(GFAP-cre)25Mes/0
• Genetic Background: B6.Cg-Hk2^tm1.1Uku Tg(GFAP-cre)25Mes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:210113 )

• cerebellar granule neuron progenitors fail to migrate over the Purkinje cell layer

abnormal neuronal precursor proliferation ( J:210113 )

• at P7, cerebellar granule neuron progenitors exhibit reduced proliferation in response to Shh compared with wild-type cells

abnormal cerebellum external granule cell layer morphology ( J:210113 )

• focal disorganization of the external granule cell layer

• regions of focal thinning or thickening, abnormal migration and increased vascularization at P7

irregular external granule cell layer thickness ( J:210113 )

• regions of focal thinning or thickening at P7

cellular

abnormal cerebellar granule cell migration ( J:210113 )

• cerebellar granule neuron progenitors fail to migrate over the Purkinje cell layer

abnormal neuronal precursor proliferation ( J:210113 )

• at P7, cerebellar granule neuron progenitors exhibit reduced proliferation in response to Shh compared with wild-type cells