Phenotypes Associated with This Genotype

Genotype
MGI:5571369

• Allelic Composition: Tg(Igh-ROR1)1Kip/0
• Genetic Background: C57BL/6-Tg(Igh-ROR1)1Kip

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:206368 )

• develops in 5% of mice

increased lymphocyte cell number ( J:206368 )

• increase in numbers of splenic lymphocytes

• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1^bright CD5+B220^low B cells

increased mature B cell number ( J:206368 )

• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

immune system

enlarged spleen ( J:206368 )

• develops in 5% of mice

increased lymphocyte cell number ( J:206368 )

• increase in numbers of splenic lymphocytes

• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1^bright CD5+B220^low B cells

increased mature B cell number ( J:206368 )

• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• 5% of mice develop clonal expansions of ROR1^bright CD5+B220^low B cells resembling human chronic lymphocytic leukemia

growth/size/body

enlarged spleen ( J:206368 )

• develops in 5% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368