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Phenotypes Associated with This Genotype
Genotype
MGI:5571369
Allelic
Composition
Tg(Igh-ROR1)1Kip/0
Genetic
Background
C57BL/6-Tg(Igh-ROR1)1Kip
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• develops in 5% of mice

hematopoietic system
• develops in 5% of mice
• increase in numbers of splenic lymphocytes
• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1bright CD5+B220low B cells
• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

immune system
• develops in 5% of mice
• increase in numbers of splenic lymphocytes
• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1bright CD5+B220low B cells
• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

neoplasm
• 5% of mice develop clonal expansions of ROR1bright CD5+B220low B cells resembling human chronic lymphocytic leukemia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory