Phenotypes Associated with This Genotype

Genotype
MGI:5570667

• Allelic Composition: Runx2^tm1.1Yyon/Runx2^tm1.1Yyon; Tg(Col2a1-cre)1Star/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:210124 )

• due to difficulty breathing

skeleton

delayed bone ossification ( J:210124 )

• almost complete absence of mineralized tissue at E15.5

• however, ossification of the facial bone, skull bone and clavicle is normal

delayed endochondral bone ossification ( J:210124 )

• in newborn mice, including long bones and vertebrae

respiratory system

respiratory distress ( J:210124 )

• difficulty breathing at birth leading to death