Phenotypes Associated with This Genotype

Genotype
MGI:5570433

• Allelic Composition: Ptges^tm1.1Gaf/Ptges^tm1.1Gaf; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice

decreased prostaglandin level ( J:210141 )

• decreased IL1beta-stimulated prostaglandin E2

increased prostaglandin level ( J:210141 )

• increased IL1beta-stimulated prostaglandin D2 and I2 levels

cardiovascular system

cardiovascular system phenotype ( J:210141 )

N • whether fed standard chow or a high salt diet, mice exhibit normal modulation of blood pressure and thrombogenesis

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice