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Phenotypes Associated with This Genotype
Genotype
MGI:5569928
Allelic
Composition
Nkx3-1tm1Mms/Nkx3-1+
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Mms mutation (3 available); any Nkx3-1 mutation (20 available)
Ptentm1Rps mutation (1 available); any Pten mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

reproductive system
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

neoplasm
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory