Phenotypes Associated with This Genotype

Genotype
MGI:5569648

• Allelic Composition: Ano1^tm2Jrr/Ano1^tm2Jrr; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129S6/SvEvTac * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine chloride ion level ( J:210158 )

• at 8 to 12 weeks

decreased urine potassium level ( J:210158 )

• at 8 to 12 weeks

decreased urine sodium level ( J:210158 )

• at 8 to 12 weeks

increased urine protein level ( J:210158 )

• at P1

• however, this difference faded as animals age

albuminuria ( J:210158 )

• macro-albuminuria

abnormal renal tubule epithelium morphology ( J:210158 )

• proximal tubular epithelial (PTE) cells exhibit accumulation of intracellular endosomal vesicles unlike in wild-type cells

• PTE cells are more hyperpolarized and acidic with decreased albumin uptake compared with wild-type cells

homeostasis/metabolism

increased circulating aldosterone level ( J:210158 )

• at 8 to 12 weeks

increased circulating renin level ( J:210158 )

• at 8 to 12 weeks

decreased urine chloride ion level ( J:210158 )

• at 8 to 12 weeks

decreased urine potassium level ( J:210158 )

• at 8 to 12 weeks

decreased urine sodium level ( J:210158 )

• at 8 to 12 weeks

increased urine protein level ( J:210158 )

• at P1

• however, this difference faded as animals age

albuminuria ( J:210158 )

• macro-albuminuria