Phenotypes Associated with This Genotype

Genotype
MGI:5569640

• Allelic Composition: Dmd^tm1.1Know/Dmd^tm1.1Know; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Tg(Myh6-2A)#Know/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Inhibition of dilated cardiomyopathy in Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

cardiovascular system

cardiac fibrosis ( J:207775 )

• less severe fibrosis in tamoxifen-treated mice

increased cardiac muscle contractility ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

abnormal heart echocardiography feature ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

cardiomyopathy ( J:207775 )

• less severe cardiomyopathy in tamoxifen-treated mice

homeostasis/metabolism

decreased susceptibility to injury ( J:207775 )

• tamoxifen-treated mice exhibit less severe cardiomyopathy, cardiac fibrosis and improved cardiac function compared with control mice

muscle

increased cardiac muscle contractility ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

cardiomyopathy ( J:207775 )

• less severe cardiomyopathy in tamoxifen-treated mice