Phenotypes Associated with This Genotype

Genotype
MGI:5569622

• Allelic Composition: Htr2c^tm2Jke/Y; Tg(Zp3-cre)93Knw/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:207704 )

• a high rate of seizure-induced mortality is observed from 6 weeks through 17 weeks

• Background Sensitivity: with further backcrossing to enrich the C57BL/6J background content, the mortality phenotype is almost eliminated

growth/size/body

increased susceptibility to diet-induced obesity ( J:207704 )

• on an obesogenic (high fat,high sugar) diet, higher rate of obesity is observed compared to controls

behavior/neurological

seizures ( J:207704 )

• mice exhibit seizure-induced death

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:207704 )

• on an obesogenic (high fat,high sugar) diet, higher rate of obesity is observed compared to controls

hyperglycemia ( J:207704 )

• mice show enhanced hyperglycemia incidence when fed an obesogenic (high fat,high sugar) diet

nervous system

seizures ( J:207704 )

• mice exhibit seizure-induced death