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Phenotypes Associated with This Genotype
Genotype
MGI:5569513
Allelic
Composition
Msrb3tm1Hyk/Msrb3tm1Hyk
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msrb3tm1Hyk mutation (0 available); any Msrb3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• mice exhibit normal vestibular behaviors
• mice exhibit normal protein oxidation in the inner ear cells
• omega-shaped arrangement of stereocilia
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• mice did not respond to click stimuli or tone bursts

cellular
N
• mice exhibit normal protein oxidation in the inner ear cells
• in the organ of Corti

nervous system
• omega-shaped arrangement of stereocilia
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Recessive 74; DFNB74 613718 J:206322


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory