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Phenotypes Associated with This Genotype
Genotype
MGI:5569513
Allelic
Composition
Msrb3tm1Hyk/Msrb3tm1Hyk
Genetic
Background
involves: 129/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msrb3tm1Hyk mutation (0 available); any Msrb3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• mice exhibit normal vestibular behaviors
• mice exhibit normal protein oxidation in the inner ear cells
• omega-shaped arrangement of stereocilia
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• mice did not respond to click stimuli or tone bursts

cellular
N
• mice exhibit normal protein oxidation in the inner ear cells
• in the organ of Corti

nervous system
• omega-shaped arrangement of stereocilia
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns
• progressive degeneration of stereocilia of the inner ear hair cells beginning at P13, more severe at P20
• degeneration is more severe in the apical turns than in the middle and basal turns

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 74 DOID:0110523 OMIM:613718
J:206322


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory