Analysis Tools
nervous system
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• after 5 weeks
• rapid decline from 13 to 25 weeks, slowed decline afterward
• at 59 to 79 weeks
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• postnatal loss of forebrain mass at 16 and 32 weeks
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• progressive cell loss
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• loss of cortical cytoarchitecture at 16 and 32 weeks
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• progressive neurodegeneration in the cerebral cortex (starting at 16 weeks) and hippocampus starting
• severely diminished at 65 weeks
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• decrease in neuronal density at 16 and 32 weeks
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• in the CA1 and subiculum
• however, the CA3 and dentate gyrus are relatively spared
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• progressive neurodegeneration in the cerebral cortex and hippocampus
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