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Phenotypes Associated with This Genotype
Genotype
MGI:5568998
Allelic
Composition
Mecp2tm1.1Jtc/Mecp2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation (1 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• object memory is intact at 1 hour, but impaired at 24 hours after object training, however, the impairment occurs to a lesser degree than in males
• females freeze for a larger percentage of time during the acquisition phase of the associative fear conditioning task as compared to wild type on day 80, but not on postnatal day 40
• reduced latency to fall from rotarod as compared to wild type on postnatal day 30
• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type on postnatal day 63
• reduced fine motor movements (repeated breaking of same beam) as compared to wild type on postnatal day 63
• tonic-clonic seizures observed in 3.7% (5/136) of females
• seizures appear to be stimulated by touch
• mice die within a month of seizures

growth/size/body
• reduced body weight as compared to wild type on postnatal day 64

nervous system
• tonic-clonic seizures observed in 3.7% (5/136) of females
• seizures appear to be stimulated by touch
• mice die within a month of seizures

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:209637


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory