About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5568994
Allelic
Composition
Mecp2tm1.1Jtc/Y
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation (1 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• object memory is intact at 1 hour, but impaired 24 hours after object training
• increased time spent in open arms as compared to wild type on postnatal day 25
• increased number of open arm entries as compared to wild type on on postnatal day 25
• increased travel distance in zero maze as compared to wild type control on postnatal day 25
• males freeze for a larger percentage of time as compared to wild type on postnatal day 35, however, males freeze for smaller percentage of time on both context and cued memory tasks
• reduced latency to fall from rotarod as compared to wild type on postnatal day 29
• decreased forelimb grip strength as compared to wild type on postnatal day 25
• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type first observed at postnatal day 24
• reduced fine motor movements (repeated breaking of same beam) as compared to wild type observed at postnatal day 43
• mice appear lethargic by postnatal day 50

growth/size/body
• reduced body weight as compared to wild type on postnatal day 25

integument
• ruffled fur observed by postnatal day 50

respiratory system
• respiratory abnormalities observed by postnatal day 50

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:209637


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory