Phenotypes Associated with This Genotype

Genotype
MGI:5568946

• Allelic Composition: Setd1a^tm1Afst/Setd1a^tm1Afst
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:208420 )

• by E7.5

embryo

failure to gastrulate ( J:208420 )

• implant but fail to gastrulate

cellular

cellular phenotype ( J:208420 )

N • display mitotic activities at E6.5

abnormal cell physiology ( J:208420 )

• embryonic stem cell lines cannot be established

abnormal DNA methylation ( J:208420 )

• 50% decrease of H3K4 methylated species in E7.5 embryos