Phenotypes Associated with This Genotype

Genotype
MGI:5568557

• Allelic Composition: Tg(Fabp4-Serpina12)1Jwada/0
• Genetic Background: involves: C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208508 )

N • mice fed a high fat, high sucrose diet exhibit normal adiponectin levels

decreased circulating insulin level ( J:208508 )

• in mice fed a high fat, high sucrose diet at 13 weeks but not 25 weeks

decreased circulating leptin level ( J:208508 )

• in mice fed a high fat, high sucrose diet at 13 weeks but not 25 weeks

decreased circulating LDL cholesterol level ( J:208508 )

• small decrease of small density LDL in mice fed a high fat, high sucrose diet

increased insulin sensitivity ( J:208508 )

• in mice fed a high fat, high sucrose diet

decreased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

liver/biliary system

decreased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

decreased liver weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

decreased susceptibility to diet-induced hepatic steatosis ( J:208508 )

• in mice fed a high fat, high sucrose diet

adipose tissue

decreased epididymal fat pad weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

growth/size/body

decreased body weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

• however, mice fed standard chow exhibit normal weight