Phenotypes Associated with This Genotype

Genotype
MGI:5568214

• Allelic Composition: Mecp2^tm1.1Jtc/Y
• Genetic Background: involves: 129S6/SvEvTac * 129/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:127431 )

♂ • male mice exhibit hindlimb clasping by 7 weeks of age

decreased locomotor activity ( J:127431 )

♂ • male mice exhibit hypoactivity

increased stereotypic behavior ( J:127431 )

♂ • male mice exhibit forelimb stereotypies

growth/size/body

abnormal body weight ( J:127431 )

♂ • male mice exhibit great variability in weight

slow postnatal weight gain ( J:127431 )

♂ • some male mice exhibit failure to thrive

obese ( J:127431 )

♂ • a subset of male mice have excessive weight gain

mortality/aging

premature death ( J:127431 )

♂ • average lifespan in males is 85.8 +/-24.2 days

respiratory system

abnormal breathing pattern ( J:127431 )

♂ • male mice exhibit breathing irregularities by 7 weeks of age