Phenotypes Associated with This Genotype

Genotype
MGI:5566523

• Allelic Composition: Tg(Pbsn-FGFR1*K656E)#Wmck/0; Tg(Pbsn-FGFR2_iiib*)#Ng/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:87067 )

♂ • develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age

♂ • lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli

♂ • disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment

♂ • neuroendocrine cell population is increased in prostates

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:87067 )

♂ • develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age

♂ • lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli

♂ • disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment

♂ • neuroendocrine cell population is increased in prostates

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:87067 )

♂ • develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age

♂ • lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli

♂ • disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment

♂ • neuroendocrine cell population is increased in prostates