Phenotypes Associated with This Genotype

Genotype
MGI:5566518

• Allelic Composition: Tg(Pbsn-FGF7)3293Ng/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:80821 )

♂ • the stromal layer is frequently disorganized

♂ • regions of smooth muscle layers associated with the ducts exhibit regions of thickening and thinning

abnormal prostate gland duct morphology ( J:80821 )

♂ • prostatic ducts are atypical and often so filled with epithelial that they lack an open lumen

abnormal prostate gland epithelium morphology ( J:80821 )

♂ • while epithelial cells or prostatic ducts are tightly associated with the basement membrane, the infoldings are shorter and more numerous

prostate gland epithelial hyperplasia ( J:80821 )

♂ • prostatic ducts have more epithelial cells and are hyperplastic

prostate gland hyperplasia ( J:80821 )

♂ • hyperplasia throughout the prostate gland with increased enfolding of the basement membrane

increased prostate intraepithelial neoplasia incidence ( J:80821 )

♂ • mice develop low-grade prostate intraepithelial neoplasia (PIN) with epithelial cells pushing through basement membrane and invading smooth muscle layer after 1 year

reproductive system

abnormal prostate gland morphology ( J:80821 )

♂ • the stromal layer is frequently disorganized

♂ • regions of smooth muscle layers associated with the ducts exhibit regions of thickening and thinning

abnormal prostate gland duct morphology ( J:80821 )

♂ • prostatic ducts are atypical and often so filled with epithelial that they lack an open lumen

abnormal prostate gland epithelium morphology ( J:80821 )

♂ • while epithelial cells or prostatic ducts are tightly associated with the basement membrane, the infoldings are shorter and more numerous

prostate gland epithelial hyperplasia ( J:80821 )

♂ • prostatic ducts have more epithelial cells and are hyperplastic

prostate gland hyperplasia ( J:80821 )

♂ • hyperplasia throughout the prostate gland with increased enfolding of the basement membrane

increased prostate intraepithelial neoplasia incidence ( J:80821 )

♂ • mice develop low-grade prostate intraepithelial neoplasia (PIN) with epithelial cells pushing through basement membrane and invading smooth muscle layer after 1 year

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:80821 )

♂ • mice develop low-grade prostate intraepithelial neoplasia (PIN) with epithelial cells pushing through basement membrane and invading smooth muscle layer after 1 year