Phenotypes Associated with This Genotype

Genotype
MGI:5566516

• Allelic Composition: Tg(Pbsn-FGFR2_iiib*)#Ng/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:80821 )

♂ • stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts

♂ • increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype

abnormal prostate gland duct morphology ( J:80821 )

♂ • epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane

♂ • some of the ducts lack an epithelial lining

abnormal prostate gland epithelium morphology ( J:80821 )

♂ • epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane

small prostate gland ( J:80821 )

♂ • all four lobes of the prostate are smaller in size

reproductive system

abnormal prostate gland morphology ( J:80821 )

♂ • stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts

♂ • increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype

abnormal prostate gland duct morphology ( J:80821 )

♂ • epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane

♂ • some of the ducts lack an epithelial lining

abnormal prostate gland epithelium morphology ( J:80821 )

♂ • epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane

small prostate gland ( J:80821 )

♂ • all four lobes of the prostate are smaller in size