Phenotypes Associated with This Genotype

Genotype
MGI:5565703

• Allelic Composition: Tg(Pbsn-FGFR1*K656E)#Wmck/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87519 )

♂ • mortality increases by 30 weeks of age, with a mortality rate of about 55% over 6-9 months of age

♂ • mortality is due to urinary restriction

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:87519 )

♂ • hyperplasia accompanied by intermediate grade prostatic intraepithelial neoplasia (PIN) is evident in enlarged prostates at 6-8 months of age

♂ • higher grade PIN appears with aging after 20 months without signs of overt invasive carcinoma

endocrine/exocrine glands

enlarged prostate gland ( J:87519 )

♂ • prostates show increased size and weight after 20 weeks of age

prostate gland hyperplasia ( J:87519 )

♂ • hyperplasia in epithelial, and to a lesser extent, stromal compartments and nuclear atypia in epithelial cells of the prostate with increasing age

increased prostate intraepithelial neoplasia incidence ( J:87519 )

♂ • hyperplasia accompanied by intermediate grade prostatic intraepithelial neoplasia (PIN) is evident in enlarged prostates at 6-8 months of age

♂ • higher grade PIN appears with aging after 20 months without signs of overt invasive carcinoma

abnormal prostate gland physiology ( J:87519 )

♂ • the prostate regenerative response to androgen is accelerated in orchiectomized mice

renal/urinary system

urethra obstruction ( J:87519 )

♂ • mice exhibit severe urinary tract obstruction most likely due to hyperplasia of the prostate

♂ • urethra is packed with noninvasive hyperplastic epithelial cells extending from the prostate

reproductive system

enlarged prostate gland ( J:87519 )

♂ • prostates show increased size and weight after 20 weeks of age

prostate gland hyperplasia ( J:87519 )

♂ • hyperplasia in epithelial, and to a lesser extent, stromal compartments and nuclear atypia in epithelial cells of the prostate with increasing age

increased prostate intraepithelial neoplasia incidence ( J:87519 )

♂ • hyperplasia accompanied by intermediate grade prostatic intraepithelial neoplasia (PIN) is evident in enlarged prostates at 6-8 months of age

♂ • higher grade PIN appears with aging after 20 months without signs of overt invasive carcinoma

abnormal prostate gland physiology ( J:87519 )

♂ • the prostate regenerative response to androgen is accelerated in orchiectomized mice

reduced male fertility ( J:87519 )

♂ • a fraction of males cease reproductive activity by 6 months of age