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Phenotypes Associated with This Genotype
Genotype
MGI:5565691
Allelic
Composition
Tg(UBC-GFP/HTT*84Q)22Shya/0
Genetic
Background
involves: FVB
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival rate at 13 months is 33%
• some mice start to die at 5 months of age and survival rate at 13 months is about 33%

behavior/neurological
• clasping behavior is seen after 8.5 months of age
• mice are unbalanced on the rotarod while running and exhibit a higher tendency to fall off during three consecutive days at the end stage
• mice show weaker grasping strength after 8.5 months of age that becomes progressively worse with age
• mice show disordered and shorter stride length, dragging, and uneven step patterns and unbalanced gaits when walking through a tunnel at the end stage
• in aged mice

nervous system
• nuclear aggregates, intranuclear aggregates, and neuropil aggregates and inclusion bodies are seen in the cortex and striatum regions at 12 months of age, but not at 2 months
• more nuclear aggregates and inclusion bodies are seen in the striatum while neuropil aggregates are predominately seen in the cortex region

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:209055


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory