About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5565512
Allelic
Composition
Flt3tm1.1Dosm/Flt3+
Genetic
Background
B6.129(C)-Flt3tm1.1Dosm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1.1Dosm mutation (0 available); any Flt3 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• detected at 12 weeks of age

mortality/aging
• median survival is 430 days

hematopoietic system
• impaired ability to engraft in a competitive repopulation assay
• severe block in B cell development with few cells progressing past the early pro-B cell stage
• normal architecture is largely replaced by myeloid progenitors in mice at 3 and 12 months of age
• decrease in the fraction of functional c-Kit+ Sca-1+ Lin-(KSL)-signaling lymphocyte activation molecule (KSL-SLAM) cells
• increase in the fractions of c-Kit+ Sca-1+ Lin- (KSL) and multipotent progenitor (Lin-c-Kit+Sca-1+CD135+CD34+) cells in the bone marrow
• architecture disruption and cellular expansion at 3 and 12 months of age
• detected at 12 weeks of age
• treatment with either Lestaurtinib or Sorafenib decreases bone marrow cell proliferation

skeleton
• architecture disruption and cellular expansion at 3 and 12 months of age
• normal architecture is largely replaced by myeloid progenitors in mice at 3 and 12 months of age

immune system
• severe block in B cell development with few cells progressing past the early pro-B cell stage
• architecture disruption and cellular expansion at 3 and 12 months of age
• detected at 12 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:205200


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2022
MGI 6.21
The Jackson Laboratory