growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points
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mortality/aging
N |
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
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• median survival time is 451 days
• 6 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time is longest on this background as compared to A/J, BALB/c, 129S6/SvEvTac, C57BL/6, 129S6B6F1 and 129S6AF1 backgrounds
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neoplasm
• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds
• 5 out of 20 males and 13 out of 20 mice die of thymic lymphomas
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