Phenotypes Associated with This Genotype

Genotype
MGI:5565479

• Allelic Composition: Atm^tm1Awb/Atm^tm1Awb
• Genetic Background: either: (129S6/SvEvTac-Atm^tm1Awb x A.129S6-Atm^tm1Awb)F1 or (A.129S6-Atm^tm1Awb x 129S6/SvEvTac-Atm^tm1Awb)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:208539 )

• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging

mortality/aging ( J:208539 )

N • Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds

premature death ( J:208539 )

• median survival time is 139 days

• 4 mice out of 39 survive to 18 months of age

• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm

increased T cell derived lymphoma incidence ( J:208539 )

• almost all mice die of thymic lymphomas

• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atm^tm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:208539 )

• almost all mice die of thymic lymphomas

• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atm^tm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds