Phenotypes Associated with This Genotype

Genotype
MGI:5565475

• Allelic Composition: Atm^tm1Awb/Atm^tm1Awb
• Genetic Background: B6.129S6-Atm^tm1Awb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:208539 )

• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging

lethality, incomplete penetrance ( J:208539 )

• heterozygote x heterozygote matings produced fewer homozygotes than the expected Mendelian ratio

• Background Sensitivity: the number of homozygous pups produced from heterozygotes on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio

premature death ( J:208539 )

• median survival time is 353 days

• 8 mice out of 40 survive to 18 months of age

• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm

abnormal tumor incidence ( J:208539 )

• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds

• 21 out of 40 mice die of thymic lymphomas