Phenotypes Associated with This Genotype

Genotype
MGI:5565458

• Allelic Composition: Braf^tm1Cpri/Braf⁺; Scn10a^tm2(cre)Jwo/Scn10a⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:205122 )

N • behavioral responses to pain and motor functions are similar to controls prior to the onset of scratching

enhanced behavioral response to xenobiotic ( J:205122 )

• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape

• both histaminergic and nonhistaminergic itch are significantly enhanced

excessive scratching ( J:205122 )

• age-dependent excessive scratching from 6 to 14 weeks of age, with about 50% of mice showing excessive scratching at 6 weeks of age

• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape

• both histaminergic and nonhistaminergic itch are significantly enhanced

integument

skin lesions ( J:205122 )

• develop after the onset of excessive scratching

nervous system

abnormal innervation ( J:205122 )

• increase in the density of primary afferent fibers innervating the cervical and lumbar back hairy skin regions

• in the spinal cord CGRP+ fibers expand into lamina II inner layer and nonpeptidergic

• IB4+ fibers invade into laminae I and II outer layer domains

abnormal dorsal root ganglion morphology ( J:205122 )

• increase in the number of pERK+ cells in dorsal root ganglion neurons at the cervical, thoracic and lumbar segmental levels

• the number of GRP+ neurons is nearly doubled

abnormal nervous system electrophysiology ( J:205122 )

• the percentage of single spike cells is decreased while the percentage of delayed firing cells is almost

abnormal neuron physiology ( J:205122 )

• increase in the percentage of dorsal root ganglion cells responding to chloroquine and histamine