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Phenotypes Associated with This Genotype
Genotype
MGI:5565367
Allelic
Composition
Mettm4Gvw/Met+
Genetic
Background
involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm4Gvw mutation (0 available); any Met mutation (82 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• both nulliparous and multiparous females develop mammary tumors with high penetrance
• mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation
• mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia
• solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells
• significant squamous metaplasia is seen in 65% of mammary tumors
• tumors are often estrogen receptor-positive and progesterone receptor-negative
• mammary adenocarcinoma with squamous metaplasia or/and with solid patterns
• mammary adenocarcinomas show high levels of Met amplification and trisomy
• mammary squamous cell carcinoma
• undifferentiated mammary sarcomas
• mammary hamangiosarcoma
• mammary myoepithelioma

endocrine/exocrine glands
• both nulliparous and multiparous females develop mammary tumors with high penetrance
• mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation
• mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia
• solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells
• significant squamous metaplasia is seen in 65% of mammary tumors
• tumors are often estrogen receptor-positive and progesterone receptor-negative
• mammary adenocarcinoma with squamous metaplasia or/and with solid patterns
• mammary adenocarcinomas show high levels of Met amplification and trisomy

integument
• both nulliparous and multiparous females develop mammary tumors with high penetrance
• mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation
• mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia
• solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells
• significant squamous metaplasia is seen in 65% of mammary tumors
• tumors are often estrogen receptor-positive and progesterone receptor-negative
• mammary adenocarcinoma with squamous metaplasia or/and with solid patterns
• mammary adenocarcinomas show high levels of Met amplification and trisomy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:151890


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory