Phenotypes Associated with This Genotype

Genotype
MGI:5564939

• Allelic Composition: Rgs9^{tm1.1(cre)Yql}/Rgs9⁺; Tg(HTT*97Q)IXwy/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:208675 )

• significantly different from wild-type (similar to BACHD (Tg(HTT*97Q)IXwy) mice); little improvement is observed

increased anxiety-related response ( J:208675 )

• significantly different from wild-type (similar to BACHD mice); little improvement is observed

impaired coordination ( J:208675 )

• mice show significant rotarod impairment between 6 and 12 months relative to wild-type

decreased locomotor activity ( J:208675 )

• reduced movement is observed at 12 months relative to wild-type

nervous system

nervous system phenotype ( J:208675 )

N • evoked synaptic NMDA currents in medium spiny neurons (MSNs) in striatal slices from 13-15 month-old mice are not significantly different from wild-type; normalized amplitudes of currents are not significantly different

forebrain atrophy ( J:208675 )

• forebrain weight loss and striatal volume loss) are observed at 12 months compared to wild-type