Phenotypes Associated with This Genotype

Genotype
MGI:5564938

• Allelic Composition: Emx1^tm1(cre)Ito/Emx1⁺; Tg(HTT*97Q)IXwy/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:208675 )

N • depression-like phenotype is not significantly different from wild-type but is significantly improved compared to BACHD (Tg(HTT*97Q)IXwy) mice

N • anxiety response is significantly improved compared to BACHD mice

impaired coordination ( J:208675 )

• mice show rotarod impairment relative to wild-type at 6 and 12 months; significant partial improvement is observed by 6 months compared to BACHD mice

decreased locomotor activity ( J:208675 )

• reduced movement is observed at 12 months compared to wild-type; significant partial improvement in the open-field is observed at 12 months compared to BACHD mice

nervous system

nervous system phenotype ( J:208675 )

N • no significant difference is observed in forebrain weight or cortical or striatal volume between either wild-type or BACHD mice

N • evoked synaptic NMDA currents in medium spiny neurons (MSNs) in striatal slices from 13-15 month-old mice are not significantly different from wild-type; normalized amplitudes of currents are not significantly different

N • spontaneous excitatory postsynaptic currents (sEPSCs) and spontaneous inhibitory postsynaptic currents (sEPSCs) in striatal medium spiny neurons (MSNs) are improved relative to BACHD neurons