Phenotypes Associated with This Genotype

Genotype
MGI:5564936

• Allelic Composition: Emx1^tm1(cre)Ito/Emx1⁺; Rgs9^{tm1.1(cre)Yql}/Rgs9⁺; Tg(HTT*97Q)IXwy/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:208675 )

N • depression-like phenotype is not significantly different from wild-type but is significantly improved compared to BACHD (Tg(HTT*97Q)IXwy) mice

N • anxiety response is significantly improved compared to BACHD mice

N • significant, consistent improvement is observed in hypoactivity phenotype at 6 and 12 months compared to BACHD mice

N • significant, consistent improvement in coordination is observed at 6 and 12 months compared to BACHD mice

nervous system

nervous system phenotype ( J:208675 )

N • forebrain weight loss and cortical/striatal volume loss are improved relative to BACHD (Tg(HTT*97Q)IXwy) mice