Phenotypes Associated with This Genotype

Genotype
MGI:5563580

• Allelic Composition: Mylk^tm1.1Bph/Mylk^tm1.1Bph; Tg(Myh11-cre,-EGFP)2Mik/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

mortality/aging

neonatal lethality, incomplete penetrance ( J:204964 )

• fewer than expected mice are born

prenatal lethality, incomplete penetrance ( J:204964 )

• fewer than expected mice are born

digestive/alimentary system

abnormal small intestine morphology ( J:204964 )

• shorter than in control mice

muscle

impaired smooth muscle contractility ( J:204964 )

• induced by high KCl, carbachol or ET1 in the colon

• however, the L-type calcium channel inhibitor diltiazem blocks contractile responses to high KCl

growth/size/body

growth/size/body region phenotype ( J:204964 )

N • mice exhibit normal body weight