Phenotypes Associated with This Genotype

Genotype
MGI:5563527

• Allelic Composition: Epm2aip1^{Gt(BA0314)Wtsi}/Epm2aip1^{Gt(BA0314)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:204966 )

• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice

• however, mice exhibit normal insulin tolerance

decreased circulating glucose level ( J:204966 )

• in fasted mice

abnormal gluconeogenesis ( J:204966 )

• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice

improved glucose tolerance ( J:204966 )

• in a glucose tolerance test, glucose clearance is increased compared with wild-type mice

abnormal glycogen homeostasis ( J:204966 )

• reduced hepatic glycogen synthesis

decreased liver glycogen level ( J:204966 )

behavior/neurological

behavior/neurological phenotype ( J:204966 )

N • mice do not exhibit epilepsy, motor deficits and ataxia

increased anxiety-related response ( J:204966 )

• in open field and startle tests

growth/size/body

decreased susceptibility to age related obesity ( J:204966 )

• in adulthood

liver/biliary system

decreased liver glycogen level ( J:204966 )

hepatic steatosis ( J:204966 )

muscle

muscle phenotype ( J:204966 )

N • skeletal muscle exhibits normal glycogen storage with no lipid accumulation