Phenotypes Associated with This Genotype

Genotype
MGI:5563523

• Allelic Composition: Fendrr^tm1Vlcg/Fendrr^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:204277 )

• die within 24 h of birth

respiratory system

abnormal lung vasculature morphology ( J:204277 )

• decrease in the number and organization of pulmonary arteries at E14.5

• general failure of vasculogenesis in the lungs at E14.5

pulmonary hypoplasia ( J:204277 )

• at E14.5

abnormal pulmonary alveolus morphology ( J:204277 )

• appear to have fewer but larger alveoli at E18.5

respiratory failure ( J:204277 )

• mice delivered surgically at E18.5 either fail to breathe or gasp and stop breathing within 5 h

digestive/alimentary system

abnormal esophagus morphology ( J:204277 )

• thinning of the mesenchymal layer of the mucosa at E18.5

abnormal esophageal smooth muscle morphology ( J:204277 )

• thinning of the external smooth muscle layers at E18.5

cardiovascular system

abnormal lung vasculature morphology ( J:204277 )

• decrease in the number and organization of pulmonary arteries at E14.5

• general failure of vasculogenesis in the lungs at E14.5

ventricular septal defect ( J:204277 )

• at E18.5

muscle

abnormal esophageal smooth muscle morphology ( J:204277 )

• thinning of the external smooth muscle layers at E18.5