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Phenotypes Associated with This Genotype
Genotype
MGI:5563481
Allelic
Composition
Bbip1tm1.1Gne/Bbip1tm1.1Gne
Genetic
Background
involves: 129 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbip1tm1.1Gne mutation (0 available); any Bbip1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: on a mixed 129 and C57BL/6 background 40% survive to weaning but no mice survive past 24-36 h after birth on a pure C57BL/6 background

growth/size/body

behavior/neurological
• administration of PYY-36 fails to inhibit food intake in a starvation-refeeding experiment, unlike in wild-type mice
• hyperphagia

nervous system
• defect in neuronal ciliary localization of SSTR3 but not MCHR1 in the hippocampus CA1 region
• absence of NPY2R in arcuate nucleus cilia; however, overall NPY2R expression levels in the hypothalamus are similar to controls

reproductive system

vision/eye

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bardet-Biedl syndrome 18 DOID:0110140 OMIM:615995
J:204140


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory