Phenotypes Associated with This Genotype

Genotype
MGI:5563350

• Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:204782 )

N • B cells exhibit normal calcium signaling

N • the proportion of T and B cells is normal

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice

increased spleen weight ( J:204782 )

• mild

increased anti-chromatin antibody level ( J:204782 )

increased anti-double stranded DNA antibody level ( J:204782 )

increased anti-single stranded DNA antibody level ( J:204782 )

glomerulonephritis ( J:204782 )

• with immune complex deposition

lung inflammation ( J:204782 )

renal/urinary system

glomerulonephritis ( J:204782 )

• with immune complex deposition

renal glomerular immunoglobulin deposits ( J:204782 )

respiratory system

lung inflammation ( J:204782 )

hematopoietic system

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice

increased spleen weight ( J:204782 )

• mild

growth/size/body

increased spleen weight ( J:204782 )

• mild

cellular

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice