Analysis Tools
behavior/neurological
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• mice exhibit normal exploration and total distance travelled in different behavioral tests
• mice exhibit normal motor function, acoustic startle, depressive-like behavior (immobilization during a forced swim test) and spatial learning (in a Morris Water Maze test)
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• in an elevated plus maze, mice spend less time in the open arms and more time in the closed arms compared with wild-type mice
• in a light dark box test, mice spend more time in the dark zone and less time in the light zone compared with wild-type mice
• in a new environment, mice exhibit increased latency to eat in the open field arena compared with wild-type mice
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nervous system
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• ventral hippocampal dentate gyrus granular neurons in male mice exhibit shorter dendritic lengths with fewer intersections compared with wild-type mice
• anterior medial bed nucleus of the stria terminalis (BNST) neurons exhibit shorter dendritic lengths with normal arborization compared with wild-type mice
• however, ventral hippocampal CA1 pyramidal-like lateral dorsal BNST neurons exhibit normal dendrite length and arborization
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homeostasis/metabolism
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• with elevated turnover of HVA/DA in the ventral hippocampus
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• reduced levels of the serotonin metabolite 5HIAA in the ventral hippocampus
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