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Phenotypes Associated with This Genotype
Genotype
MGI:5563093
Allelic
Composition
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable

nervous system
• cells spread less when plated on laminin compared to wild-type cells
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• occasional
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon

cellular
• cells spread less when plated on laminin compared to wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory