Mouse Genome Informatics
hm
    Slit3tm1.1Dor/Slit3tm1.1Dor
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions
• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced
• vascular density and sprouting in diaphragmatic muscle is reduced

muscle
• vascular density and sprouting in diaphragmatic muscle is reduced
• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels
• tip endothelial cells are reduced by 89% in diaphragms
• 86% of mice exhibit central tendon congenital diaphragmatic hernia
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

skeleton
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

Mouse Models of Human Disease
OMIM IDRef(s)
Diaphragmatic Hernia, Congenital 142340 J:208012