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Phenotypes Associated with This Genotype
Genotype
MGI:5562646
Allelic
Composition
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)
• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced (J:208012)
• vascular density and sprouting in diaphragmatic muscle is reduced (J:208012)
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)
• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced (J:208012)
• vascular density and sprouting in diaphragmatic muscle is reduced (J:208012)

muscle
• vascular density and sprouting in diaphragmatic muscle is reduced (J:208012)
• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels (J:208012)
• tip endothelial cells are reduced by 89% in diaphragms (J:208012)
• vascular density and sprouting in diaphragmatic muscle is reduced (J:208012)
• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels (J:208012)
• tip endothelial cells are reduced by 89% in diaphragms (J:208012)
• 86% of mice exhibit central tendon congenital diaphragmatic hernia (J:208012)
• 86% of mice exhibit central tendon congenital diaphragmatic hernia (J:208012)
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)

skeleton
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions (J:208012)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:208012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory